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There are three major highways that run through the city, Highways 16 and 35 which intersect at the City of Carthage and Highway 25 that runs through the city and is four lane from Jackson to Starkville.
Located in the center of the state, Carthage allows businesses to be in close proximity to larger metropolitan areas. The capital city of Jackson and the Jackson International Airport are located only 50 miles southwest of Carthage. The Pearl River Resort is only 20 miles east of Carthage, and the Nissan interchange is only 35 miles from Carthage.
Carthage is also near several other major roadways:
- 30 miles from Interstate 20 at Forest
- 33 miles from Interstate 55 at Canton
- 44 miles from Interstate 55 at Vaiden
- 59 miles from Interstate 59 at Meridian
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